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| Macari,Patrícia de Almeida Telles; Portela,Cíntia Nicácio; Pohlit,Adrian Martin. |
| Maytenus guyanensis Klotzch. is an Amazonian medicinal tree species known in Brazil by the common name chichuá and in Peru and Colombia by the name chuchuhuasi. It is used in traditional medicine as stimulant, tonic, and muscle relaxant, for the relief of arthritis, rheumatism, hemorrhoids, swollen kidney, skin eruptions, and skin cancer prevention, among others. Initially, different extraction solvents and methods were applied to dried, ground bark which made possible the preparation of extracts having both significant lethality to brine shrimp larvae (Artemia franciscana Leach) as well as antioxidant activity in vitro based on tests involving reactions with 2,2,-diphenyl-1-picrylhydrazyl (DPPH). Analysis of fractions from serial extractions with solvents... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Brine shrimp assay Artemia franciscana Leach 2; 2'-diphenyl-1-picrylhydrazyl DPPH beta-carotene. |
| Ano: 2006 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0044-59672006000400012 |
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| Morais,Sabrina Kelly Reis de; Silva,Suniá Gomes; Portela,Cíntia Nicácio; Nunomura,Sergio Massayoshi; Quignard,Etienne Louis Jacques; Pohlit,Adrian Martin. |
| Tabebuia incana A.H. Gentry (Bignoniaceae) is a tree from the Brazilian Amazon having medicinal uses and is one several Tabebuia spp. known as pau d'arco or palo de arco in this region. Fractionation of the bark ethanolic extract afforded a mixture of 5 and 8-hydroxy-2-(1-hydroxyethyl)naphtho[2,3-b]furan-4,9-diones (1 and 2, respectively) identified on the basis of nuclear magnetic resonance (NMR), infrared (IR) and mass (MS) spectra, whose in vitro antimalarial and antitumor activity have been shown previously. This is the first study on T. incana bark, and 2 are described in this species for the first time. Also, high performance liquid chromatography (HPLC) analysis of T. incana bark tea revealed the presence of the 1 + 2 mixture peak corresponding to a... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Artemia franciscana Leach 5-hydroxy-2-(1-hydroxyethyl)naphtho[2; 3-b]furan-4; 9-dione; 8-hydroxy-2-(1-hydroxyethyl)naphtho[2; 3-b]furan-4; 9-dione. |
| Ano: 2007 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0044-59672007000100011 |
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| Silva,Ellen Cristina Costa da; Amorim,Rodrigo César das Neves; Tadei,Wanderli Pedro; Pohlit,Adrian Martin. |
| Quassinoids neosergeolide and isobrucein B, obtained from Picrolemma sprucei, have proven in vitro antitumor, antimalarial, anthelminthic, cytotoxic, insecticide and leishmanicidal activities. There is interest in the in vivo pharmacological study of these natural compounds and their semi-synthetic derivatives, however, the quantities obtained in previous extraction processes have been shown to be a limiting factor for continuation of these studies. Herein, we describe a method for obtaining grams of these quassinoids whose purification relies only on recrystallization. |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Caferana; Simaroubaceae; Quassinoid; Recrystallization. |
| Ano: 2009 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0044-59672009000100026 |
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| Oliveira,Viviana Maria Araújo de; Carneiro,Ana Lucia Basilio; Cauper,Glaucia Socorro de Barros; Pohlit,Adrian Martin. |
| In the present study, different aerial parts from twelve Amazonian plant species found in the National Institute for Amazon Research's (INPA's) Adolpho Ducke Forest Reserve (in Manaus, Amazonas, Brazil) were collected. Separate portions of dried, ground plant materials were extracted with water (by infusion), methanol and chloroform (by continuous liquid-solid extraction) and solvents were removed first by rotary evaporation, and finally by freeze-drying which yielded a total of seventy-one freeze-dried extracts for evaluation. These extracts were evaluated initially at concentrations of 500 and 100 µg/mL for in vitro hemolytic activity and in vitro inhibition of platelet aggregation in human blood, respectively. Sixteen extracts (23 % of all extracts... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Adolpho Ducke Reserve; Chaunochiton kappleri; Diclinanona calycina; Elaeoluma nuda. |
| Ano: 2009 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0044-59672009000400026 |
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| Nunomura,Rita de Cássia Saraiva; Silva,Ellen Cristina Costa da; Oliveira,Denilson Ferreira; Garcia,Adriana Mello; Boeloni,Jankerle Neves; Nunomura,Sergio Massayoshi; Pohlit,Adrian Martin. |
| 1300 ppm (1.3 g / L), water and ethanol extracts prepared from stems or roots of Picrolemma sprucei Hook. f. were lethal (85-90 % mortality) in vitro to Haemonchus contortus (Barber Pole Worm) larvae, a gastrointestinal nematode parasite found in domestic and wild ruminants. Neosergeolide and isobrucein B were isolated in 0.0083 and 0.0070 % yield from dry, ground P. sprucei stems (0.89 kg). Neosergeolide, isobrucein B and the anthelmintic drug standard levamisole all caused comparable mortality rates (68-77 %) in vitro to H. contortus at similar concentrations (81-86 ppm). The anthelmintic activity of P. sprucei infusions (teas), alcohol extracts, and neosergeolide and isobrucein B, has therefore been demonstrated for the first time. |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Picrolemma pseudocoffea Ducke; Haemonchus contortus; Neosergeolide; Isobrucein B; Caferana. |
| Ano: 2006 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0044-59672006000300006 |
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| Pohlit,Adrian Martin; Quinard,Etienne Louis Jacques; Nunomura,Sergio Massayoshi; Tadei,Wanderli Pedro; Hidalgo,Ari de Freitas; Pinto,Ana Cristina da Silva; Santos,Elba Vieira Mustafa dos; Morais,Sabrina Kelly Reis de; Saraiva,Rita De Cássia Guedes; Ming,Lin Chau; Alecrim,Alexandre Mascarenhas; Ferraz,Alfeu de Barros; Pedroso,Andreza Cristiana da Silva; Diniz,Elisangela Vieira; Finney,Ellen Kathryn; Gomes,Erika de Oliveira; Dias,Hercules Bezerra; Souza,Katiuscia dos Santos de; Oliveira,Laura Cristina Pereira de; Don,Luciana de Castro; Queiroz,Maria Mireide Andrade; Henrique,Marycleuma Campos; Santos,Mirian dos; Lacerda Júnior,Orivaldo da Silva; Pinto,Patrícia de Souza; Silva,Suniá Gomes; Graça,Yara Rodrigues. |
| Ethanol, methanol and water extracts representing mostly native plant species found in the Amazon region were prepared, respectively, by maceration, continuous liquid-solid extraction and infusion, followed by evaporation and freeze-drying. The freeze-dried extracts were tested for lethality toward Aedes aegypti larvae at test concentrations of 500 mg / mL. In general, methanol extracts exhibited the greatest larvicidal activity. The following 7 methanol extracts of (the parts of) the indicated plant species were the most active, resulting in 100% mortality in A. aegypti larvae: Tapura amazonica Poepp. (root), Piper aduncum L. (leaf and root), P. tuberculatum Jacq. (leaf, fruit and branch). and Simaba polyphylla (Cavalcante) W.W. Thomas (branch). |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Larvicide; Aedes aegypti; Tapura; Piper; Simaba; Amazonia. |
| Ano: 2004 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0044-59672004000100012 |
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